Bacterial flagellar capping proteins adopt diverse oligomeric states

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Bacterial flagellar capping proteins adopt diverse oligomeric states

Flagella are crucial for bacterial motility and pathogenesis. The flagellar capping protein (FliD) regulates filament assembly by chaperoning and sorting flagellin (FliC) proteins after they traverse the hollow filament and exit the growing flagellum tip. In the absence of FliD, flagella are not formed, resulting in impaired motility and infectivity. Here, we report the 2.2 Å resolution X-ray c...

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The bacterial flagellar protein export apparatus processively transports flagellar proteins even with extremely infrequent ATP hydrolysis

For self-assembly of the bacterial flagellum, a specific protein export apparatus utilizes ATP and proton motive force (PMF) as the energy source to transport component proteins to the distal growing end. The export apparatus consists of a transmembrane PMF-driven export gate and a cytoplasmic ATPase complex composed of FliH, FliI and FliJ. The FliI(6)FliJ complex is structurally similar to the...

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What do you think of the state of biology today? It has indeed changed in many ways, and to the good. Molecular biology has come into its own and provides enormous power to answer new and old questions in such areas as development, physiology, and cell biology. The use of mathematical tools has become increasingly effective in shedding light on ecological and evolutionary problems, and other ma...

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ژورنال

عنوان ژورنال: eLife

سال: 2016

ISSN: 2050-084X

DOI: 10.7554/elife.18857